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Home » heritability » Recent Articles:

Still Chasing Ghosts: A New Genetic Methodology Will Not Find the “Missing Heritability”

September 19, 2013 Commentaries, Health 26 Comments
Search for the missing heritability

By Evan Charney, Duke Institute for Brain Science, Duke University

One of the hopes and promises of the Human Genome Sequencing Project was that it would revolutionize the understanding, diagnosis, and treatment of most human disorders. It would do this by uncovering the supposed “genetic bases” of human behavior. With a few exceptions, however, the search for common gene variants -“polymorphisms” – associated with common diseases has borne little fruit. And when such associations have been found the polymorphisms seem to have little predictive value and do little to advance our understanding of the causes of disease. In a 2012 study, for example, researchers found that incorporating genetic information did not improve doctors’ ability to predict disease risk for breast cancer, Type 2 diabetes, and rheumatoid arthritis [1]. … Continue Reading

Science and Social Control: Political Paralysis and the Genetics Agenda


By Jonathan Latham, PhD (Originally posted July 31st and lost after a DDOS (electronic) attack).

Variations in individual “educational attainment” (essentially, whether students complete high school or college) cannot be attributed to inherited genetic differences. That is the finding of a new study reported in Science magazine (Rietveld et al. 2013). According to this research, fully 98% of all variation in educational attainment is accounted for by factors other than a person’s simple genetic makeup.

This implies that most of student success is a consequence of potentially alterable social or environmental factors. This is an important and perhaps surprising observation, of high interest to parents, teachers, and policymakers alike; but it did not make the headlines.

The likely reason is that the authors of the study failed to mention the 98% figure in the title, or in the summary. Nor was it mentioned in the accompanying press release. … Continue Reading

‘Phantom Heritability’ Indicates Poor Predictive Value of Gene Tests

DNA Sequencing Machines

Helen Wallace, GeneWatch UK (photo credit: jurvetson)

Last week, a paper on “phantom heritability” was published by a research group led by Eric Lander, one of the leading contributors to understanding the implications of the Human Genome Project (HGP) for common, complex diseases such as heart disease and cancer (1). The paper has created excitement amongst scientists who have been critical of the claims made for the likely impacts of the HGP on health and medicine. This is not because the paper makes a startling new discovery, but because it is an important step towards recognition of these long standing criticisms. … Continue Reading

23andMe disproves its own business model

July 7, 2011 Health, News 2 Comments

Jonathan Latham

Online gene testing company 23andMe last week published its first genetic research study into Parkinson’s Disease. The study was funded by the participants (many of whom are customers of 23andMe), the company itself, and Google-founder Sergei Brin, who is married to 23andMe’s CEO and founder, Anne Wojcicki (1). Wojcicki is also personally subsidising the company and is a co-author on the paper.

23andMe’s study shows that two new genes it has discovered, plus all known existing genes linked to the disease, are not much better than random selection for predicting who will get Parkinson’s Disease. … Continue Reading

The Great DNA Data Deficit: Are Genes for Disease a Mirage?

Are Genes for Disease a Mirage?

Jonathan Latham and Allison Wilson

Just before his appointment as head of the US National Institutes of Health (NIH), Francis Collins, the most prominent medical geneticist of our time, had his own genome scanned for disease susceptibility genes. He had decided, so he said, that the technology of personalised genomics was finally mature enough to yield meaningful results. Indeed, the outcome of his scan inspired The Language of Life, his recent book which urges every individual to do the same and secure their place on the personalised genomics bandwagon.

… Continue Reading

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Why the United States Leaves Deadly Chemicals on the Market


By Valerie Brown and Elizabeth Grossman Scientists are trained to express themselves rationally. They avoid personal attacks when they disagree. But some scientific arguments become so polarized that tempers fray. There may even be shouting. Such is the current state of affairs between two camps of scientists: health effects researchers …

Why Andrew Cuomo’s Pollinator Task Force Won’t Save New York’s Bees

Bombus affinis, the Rusty-Patched Bumblebee

By Tracy Frisch As in other parts of North America, beekeepers in New York have been experiencing unsustainable losses of honeybee colonies. In 2014-15, annual colony losses in New York reached 54 per cent, according to the Bee Informed Partnership survey. And though losses were lower in preceding years, they …

Why Cancer Research Has Stalled

T. Colin Campbell

By T. Colin Campbell (Jacob Gould Schurman Professor Emeritus, Cornell University) A recent publication, which received sustained media attention, claimed that most cancers are just “bad luck” (Tomasetti and Vogelstein 2015). Its authors stated that only about one-third of cancer mutations are caused by known lifestyle or environmental factors (smoking, alcohol …

The Puppetmasters of Academia (or What the NY Times Left out)

Food Industry Enlisted Academics

by Jonathan Latham, PhD “Reading the emails make(s) me want to throw up” tweeted the Food Babe after reading a lengthy series of them posted online by the NY Times on Sept 5th. The emails in question result from a Freedom of Information Act (FOIA) request and are posted in …

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Poison Spring: The Secret History of Pollution and the EPA

Poison Spring Evaggelos Valllianatos

Book Author: Evaggelos Vallianatos with McKay Jenkins Reviewed by: Carol Van Strum “Science is the belief in the ignorance of experts,” Richard Feynman famously declared in 1966. Ever quick to challenge accepted wisdom, he distinguished the laudable ignorance of science, forever seeking unattainable certainties, from the dangerous ignorance of experts …

The Real Cost of Fracking: How America’s Shale Gas Boom Is Threatening Our Families, Pets, and Food

The Real Cost of Fracking book cover

Book Authors: Michelle Bamberger and Robert Oswald Reviewed by Allison Wilson (The Bioscience Resource Project) The first researchers to systematically document ill health in livestock, pets, and people living near fracking drill sites were Michelle Bamberger and Robert Oswald. Bamberger, a veterinarian, and Oswald, a professor of molecular medicine at …

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