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Still Chasing Ghosts: A New Genetic Methodology Will Not Find the “Missing Heritability”

September 19, 2013 Commentaries, Health 24 Comments
Search for the missing heritability

By Evan Charney, Duke Institute for Brain Science, Duke University

One of the hopes and promises of the Human Genome Sequencing Project was that it would revolutionize the understanding, diagnosis, and treatment of most human disorders. It would do this by uncovering the supposed “genetic bases” of human behavior. With a few exceptions, however, the search for common gene variants -“polymorphisms” – associated with common diseases has borne little fruit. And when such associations have been found the polymorphisms seem to have little predictive value and do little to advance our understanding of the causes of disease. In a 2012 study, for example, researchers found that incorporating genetic information did not improve doctors’ ability to predict disease risk for breast cancer, Type 2 diabetes, and rheumatoid arthritis [1]. … Continue Reading

Science and Social Control: Political Paralysis and the Genetics Agenda

NIH_1crop2

By Jonathan Latham, PhD (Originally posted July 31st and lost after a DDOS (electronic) attack).

Variations in individual “educational attainment” (essentially, whether students complete high school or college) cannot be attributed to inherited genetic differences. That is the finding of a new study reported in Science magazine (Rietveld et al. 2013). According to this research, fully 98% of all variation in educational attainment is accounted for by factors other than a person’s simple genetic makeup.

This implies that most of student success is a consequence of potentially alterable social or environmental factors. This is an important and perhaps surprising observation, of high interest to parents, teachers, and policymakers alike; but it did not make the headlines.

The likely reason is that the authors of the study failed to mention the 98% figure in the title, or in the summary. Nor was it mentioned in the accompanying press release. … Continue Reading

‘Phantom Heritability’ Indicates Poor Predictive Value of Gene Tests

DNA Sequencing Machines

Helen Wallace, GeneWatch UK (photo credit: jurvetson)

Last week, a paper on “phantom heritability” was published by a research group led by Eric Lander, one of the leading contributors to understanding the implications of the Human Genome Project (HGP) for common, complex diseases such as heart disease and cancer (1). The paper has created excitement amongst scientists who have been critical of the claims made for the likely impacts of the HGP on health and medicine. This is not because the paper makes a startling new discovery, but because it is an important step towards recognition of these long standing criticisms. … Continue Reading

23andMe disproves its own business model

July 7, 2011 Health, News 1 Comment

Jonathan Latham

Online gene testing company 23andMe last week published its first genetic research study into Parkinson’s Disease. The study was funded by the participants (many of whom are customers of 23andMe), the company itself, and Google-founder Sergei Brin, who is married to 23andMe’s CEO and founder, Anne Wojcicki (1). Wojcicki is also personally subsidising the company and is a co-author on the paper.

23andMe’s study shows that two new genes it has discovered, plus all known existing genes linked to the disease, are not much better than random selection for predicting who will get Parkinson’s Disease. … Continue Reading

The Great DNA Data Deficit: Are Genes for Disease a Mirage?

Are Genes for Disease a Mirage?

Jonathan Latham and Allison Wilson

Just before his appointment as head of the US National Institutes of Health (NIH), Francis Collins, the most prominent medical geneticist of our time, had his own genome scanned for disease susceptibility genes. He had decided, so he said, that the technology of personalised genomics was finally mature enough to yield meaningful results. Indeed, the outcome of his scan inspired The Language of Life, his recent book which urges every individual to do the same and secure their place on the personalised genomics bandwagon.

… Continue Reading

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Commentaries

How EPA Faked the Entire Science of Sewage Sludge Safety: A Whistleblower’s Story

Science for Sale by David Lewis

US EPA’s 503 sludge rule (1993) allows treated sewage sludges, aka biosolids, to be land-applied to farms, forests, parks, school playgrounds, home gardens and other private and public lands. According to a recent EPA survey, biosolids contain a wide range of mutagenic and neurotoxic chemicals, which are present at a …

Genetic Testing of Citizens Is a Backdoor into Total Population Surveillance by Governments and Companies

DNA

by Helen Wallace, GeneWatch UK The new Chief Executive of the National Health Service (NHS) in England, Simon Stevens, was recently reported arguing that the NHS must be transformed to make people’s personal genetic information the basis of their treatments (1). His proposition is unsurprising since it is in line …

The Failing Animal Research Paradigm for Human Disease

Army Medical Mouse School Research

by John J. Pippin, M.D., F.A.C.C. “The history of cancer research has been a history of curing cancer in the mouse. We have cured mice of cancer for decades—and it simply didn’t work in humans.” This statement was made by Richard Klausner, M.D., former director of the National Cancer Institute, …

What Will the World Inherit From GE Salmon?

Salmon Farming

By Dr. Gerry Goeden It’s true; about 50 percent of the fish we eat are farmed. There is good reason for this as, one by one, the world’s commercial fisheries collapse through overfishing. According to FAO (2010), 70% of the world’s large commercial fisheries have either failed or are not …

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Reviews

Biology as Ideology: The Doctrine of DNA

Biology as Ideology

Author: by Richard Lewontin ISBN: 0140232192 Publisher: Penguin books (1991) Biologists know that complex traits are typically associated with genetic variation between individuals. Nevertheless, if we hear on the news that obesity, antisocial behaviour or some other disorder has a strong genetic component, we are likely to attach special significance …

The Unsettling of America

The Unsettling of America

Author: Wendell Berry ISBN: 0871568772 Publisher: Sierra Club books (1977) In 2002, peasant associations from all over Asia organised an international scientific conference. The motivation for the conference was the fact that peasants and their leaders had no dialogue with agricultural scientists, either from their own countries or with those …

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