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The Experiment Is on Us: Science of Animal Testing Thrown into Doubt

by Pat Dutt and Jonathan Latham, PhD

New scientific research has cast grave doubt on the safety testing of hundreds of thousands of consumer products, food additives and industrial chemicals.

Everyday products, from soft drinks and baby foods, to paints, gardening products, cosmetics and shampoos, contain numerous synthetic chemicals as preservatives, dyes, active ingredients, or as contaminants. Official assurances of the safety of these chemicals are based largely on animal experiments that use rabbits, mice, rats and dogs. But new results from a consortium of researchers and published in the Proceedings of the National Academy of Sciences suggest such assurances may be worthless (Seok et al. 2013). … Continue Reading

Biology as Ideology: The Doctrine of DNA

May 13, 2012 Health, Reviews Comments Off
Biology as Ideology

Book Author: Richard Lewontin

Reviewed by: Jonathan Latham (The Bioscience Resource Project)

Biologists know that complex traits are typically associated with genetic variation between individuals. Nevertheless, if we hear on the news that obesity, antisocial behaviour or some other disorder has a strong genetic component, we are likely to attach special significance to this ‘fact’. We may be less likely to attribute social factors as a cause and we may be more likely to accept a technological or pharmaceutical solution as a remedy. The disorder may also acquire a credibility and a sense of inevitability that it previously lacked. The reasoning that leads to these conclusions has a certain logic, after all we investigate causes primarily so that we can find remedies, but nevertheless we need to be careful that our thinking is well-founded.

… Continue Reading

Psychiatrists plead to continue funding of genetic approaches to disease

August 30, 2011 Health, News 5 Comments

Jonathan Latham

Ninety six leading psychiatric geneticists have publicly requested their scientific funding agencies not to abandon the search for genetic links to mental health. In a letter, published Aug 9th in the journal Molecular Psychiatry, they argue that the ongoing failure to uncover significant disease genes for mental illness does not indicate that current research is fundamentally misdirected.

Instead, they believe that current experimental designs lack sufficient statistical power. And it is a defect they want remedied by further studies. “Since family history is a major risk factor” they write “we urge the major funding bodies worldwide to continue to support GWAS (Genome-Wide Association Studies) as a major investigative tool’. … Continue Reading

23andMe disproves its own business model

July 7, 2011 Health, News 2 Comments

Jonathan Latham

Online gene testing company 23andMe last week published its first genetic research study into Parkinson’s Disease. The study was funded by the participants (many of whom are customers of 23andMe), the company itself, and Google-founder Sergei Brin, who is married to 23andMe’s CEO and founder, Anne Wojcicki (1). Wojcicki is also personally subsidising the company and is a co-author on the paper.

23andMe’s study shows that two new genes it has discovered, plus all known existing genes linked to the disease, are not much better than random selection for predicting who will get Parkinson’s Disease. … Continue Reading

The Great DNA Data Deficit: Are Genes for Disease a Mirage?

Are Genes for Disease a Mirage?

Jonathan Latham and Allison Wilson

Just before his appointment as head of the US National Institutes of Health (NIH), Francis Collins, the most prominent medical geneticist of our time, had his own genome scanned for disease susceptibility genes. He had decided, so he said, that the technology of personalised genomics was finally mature enough to yield meaningful results. Indeed, the outcome of his scan inspired The Language of Life, his recent book which urges every individual to do the same and secure their place on the personalised genomics bandwagon.

… Continue Reading

Study Questions Application of Animal Experiments to Humans

March 30, 2007 Health, News Comments Off

Jonathan Latham and Allison Wilson

Much of science, including healthcare research and important fields of risk assessment, depend, in part or in whole, on the presumption that animal models can usefully predict human responses to treatments. However, relatively little research has been done to test this assumption. A new study has compared the results of animal experiments and human clinical trials. The study selected six treatments in which the human clinical trials had shown a clear result (either benefit or harm). They compared these to the results of animal tests. In three cases the results were in concordance while in the other three they were not.
… Continue Reading

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Commentaries

How EPA Faked the Entire Science of Sewage Sludge Safety: A Whistleblower’s Story

Science for Sale by David Lewis

US EPA’s 503 sludge rule (1993) allows treated sewage sludges, aka biosolids, to be land-applied to farms, forests, parks, school playgrounds, home gardens and other private and public lands. According to a recent EPA survey, biosolids contain a wide range of mutagenic and neurotoxic chemicals, which are present at a …

Genetic Testing of Citizens Is a Backdoor into Total Population Surveillance by Governments and Companies

DNA

by Helen Wallace, GeneWatch UK The new Chief Executive of the National Health Service (NHS) in England, Simon Stevens, was recently reported arguing that the NHS must be transformed to make people’s personal genetic information the basis of their treatments (1). His proposition is unsurprising since it is in line …

The Failing Animal Research Paradigm for Human Disease

Army Medical Mouse School Research

by John J. Pippin, M.D., F.A.C.C. “The history of cancer research has been a history of curing cancer in the mouse. We have cured mice of cancer for decades—and it simply didn’t work in humans.” This statement was made by Richard Klausner, M.D., former director of the National Cancer Institute, …

What Will the World Inherit From GE Salmon?

Salmon Farming

By Dr. Gerry Goeden It’s true; about 50 percent of the fish we eat are farmed. There is good reason for this as, one by one, the world’s commercial fisheries collapse through overfishing. According to FAO (2010), 70% of the world’s large commercial fisheries have either failed or are not …

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Reviews

The Real Cost of Fracking: How America’s Shale Gas Boom Is Threatening Our Families, Pets, and Food

The Real Cost of Fracking book cover

Book Authors: Michelle Bamberger and Robert Oswald Reviewed by Allison Wilson (The Bioscience Resource Project) The first researchers to systematically document ill health in livestock, pets, and people living near fracking drill sites were Michelle Bamberger and Robert Oswald. Bamberger, a veterinarian, and Oswald, a professor of molecular medicine at …

Biology as Ideology: The Doctrine of DNA

Biology as Ideology

Book Author: Richard Lewontin Reviewed by: Jonathan Latham (The Bioscience Resource Project) Biologists know that complex traits are typically associated with genetic variation between individuals. Nevertheless, if we hear on the news that obesity, antisocial behaviour or some other disorder has a strong genetic component, we are likely to attach …

More Reviews...