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The Experiment Is on Us: Science of Animal Testing Thrown into Doubt

by Pat Dutt and Jonathan Latham, PhD

New scientific research has cast grave doubt on the safety testing of hundreds of thousands of consumer products, food additives and industrial chemicals.

Everyday products, from soft drinks and baby foods, to paints, gardening products, cosmetics and shampoos, contain numerous synthetic chemicals as preservatives, dyes, active ingredients, or as contaminants. Official assurances of the safety of these chemicals are based largely on animal experiments that use rabbits, mice, rats and dogs. But new results from a consortium of researchers and published in the Proceedings of the National Academy of Sciences suggest such assurances may be worthless (Seok et al. 2013). … Continue Reading

Biology as Ideology: The Doctrine of DNA

May 13, 2012 Health, Reviews Comments Off on Biology as Ideology: The Doctrine of DNA
Biology as Ideology

Book Author: Richard Lewontin

Reviewed by: Jonathan Latham (The Bioscience Resource Project)

Biologists know that complex traits are typically associated with genetic variation between individuals. Nevertheless, if we hear on the news that obesity, antisocial behaviour or some other disorder has a strong genetic component, we are likely to attach special significance to this ‘fact’. We may be less likely to attribute social factors as a cause and we may be more likely to accept a technological or pharmaceutical solution as a remedy. The disorder may also acquire a credibility and a sense of inevitability that it previously lacked. The reasoning that leads to these conclusions has a certain logic, after all we investigate causes primarily so that we can find remedies, but nevertheless we need to be careful that our thinking is well-founded.

… Continue Reading

Psychiatrists plead to continue funding of genetic approaches to disease

August 30, 2011 Health, News 5 Comments

Jonathan Latham

Ninety six leading psychiatric geneticists have publicly requested their scientific funding agencies not to abandon the search for genetic links to mental health. In a letter, published Aug 9th in the journal Molecular Psychiatry, they argue that the ongoing failure to uncover significant disease genes for mental illness does not indicate that current research is fundamentally misdirected.

Instead, they believe that current experimental designs lack sufficient statistical power. And it is a defect they want remedied by further studies. “Since family history is a major risk factor” they write “we urge the major funding bodies worldwide to continue to support GWAS (Genome-Wide Association Studies) as a major investigative tool’. … Continue Reading

23andMe disproves its own business model

July 7, 2011 Health, News 2 Comments

Jonathan Latham

Online gene testing company 23andMe last week published its first genetic research study into Parkinson’s Disease. The study was funded by the participants (many of whom are customers of 23andMe), the company itself, and Google-founder Sergei Brin, who is married to 23andMe’s CEO and founder, Anne Wojcicki (1). Wojcicki is also personally subsidising the company and is a co-author on the paper.

23andMe’s study shows that two new genes it has discovered, plus all known existing genes linked to the disease, are not much better than random selection for predicting who will get Parkinson’s Disease. … Continue Reading

The Great DNA Data Deficit: Are Genes for Disease a Mirage?

Are Genes for Disease a Mirage?

Jonathan Latham and Allison Wilson

Just before his appointment as head of the US National Institutes of Health (NIH), Francis Collins, the most prominent medical geneticist of our time, had his own genome scanned for disease susceptibility genes. He had decided, so he said, that the technology of personalised genomics was finally mature enough to yield meaningful results. Indeed, the outcome of his scan inspired The Language of Life, his recent book which urges every individual to do the same and secure their place on the personalised genomics bandwagon.

… Continue Reading

Study Questions Application of Animal Experiments to Humans

March 30, 2007 Health, News Comments Off on Study Questions Application of Animal Experiments to Humans

Jonathan Latham and Allison Wilson

Much of science, including healthcare research and important fields of risk assessment, depend, in part or in whole, on the presumption that animal models can usefully predict human responses to treatments. However, relatively little research has been done to test this assumption. A new study has compared the results of animal experiments and human clinical trials. The study selected six treatments in which the human clinical trials had shown a clear result (either benefit or harm). They compared these to the results of animal tests. In three cases the results were in concordance while in the other three they were not.
… Continue Reading

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Commentaries

God’s Red Pencil? CRISPR and The Three Myths of Precise Genome Editing

crispr-cas9

by Jonathan Latham, PhD For the benefit of those parts of the world where public acceptance of biotechnology is incomplete, a public relations blitz is at full tilt. It concerns an emerging set of methods for altering the DNA of living organisms. “Easy DNA Editing Will Remake the World. Buckle …

Biofuel or Biofraud? The Vast Taxpayer Cost of Failed Cellulosic and Algal Biofuels

The now-bankrupt Kior site in Columbus, Mississippi

By Almuth Ernsting Biofuels consumed today are usually ethanol made from the sugar in sugar cane (or sugar beet) or they may be made from starch in grains. In the US this is mostly corn starch. Alternatively, biodiesel may be made from plant oils such as soybean or canola oil.

Why Chimpanzee-Testing in Medicine Had to End

Tracy at Chimp Haven

by John J. Pippin, M.D., F.A.C.C. A French man died last month and five others in the same clinical trial were hospitalized after they took an experimental drug. The drug had been deemed safe for humans after having been tested on chimpanzees in preclinical trials.

The Centrality of Seed: Building Agricultural Resilience Through Plant Breeding

Wheat Breeding

by Salvatore Ceccarelli, PhD Five of the global issues most frequently debated today are the decline of biodiversity in general and of agrobiodiversity in particular, climate change, hunger and malnutrition, poverty and water. Seed is central to all five issues. The way in which seed is produced has been arguably …

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Reviews

Poison Spring: The Secret History of Pollution and the EPA

Poison Spring Evaggelos Valllianatos

Book Author: Evaggelos Vallianatos with McKay Jenkins Reviewed by: Carol Van Strum “Science is the belief in the ignorance of experts,” Richard Feynman famously declared in 1966. Ever quick to challenge accepted wisdom, he distinguished the laudable ignorance of science, forever seeking unattainable certainties, from the dangerous ignorance of experts …

The Real Cost of Fracking: How America’s Shale Gas Boom Is Threatening Our Families, Pets, and Food

The Real Cost of Fracking book cover

Book Authors: Michelle Bamberger and Robert Oswald Reviewed by Allison Wilson (The Bioscience Resource Project) The first researchers to systematically document ill health in livestock, pets, and people living near fracking drill sites were Michelle Bamberger and Robert Oswald. Bamberger, a veterinarian, and Oswald, a professor of molecular medicine at …

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