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The Failing Animal Research Paradigm for Human Disease

Army Medical Mouse School Research

by John J. Pippin, M.D., F.A.C.C.

“The history of cancer research has been a history of curing cancer in the mouse. We have cured mice of cancer for decades—and it simply didn’t work in humans.” This statement was made by Richard Klausner, M.D., former director of the National Cancer Institute, to the Los Angeles Times (Cimons 1998). It is a statement that applies equally to many other common diseases. A decade ago, researchers reported on the existence of 195 published methods that prevented or delayed the development of type 2 diabetes in mice (Roep et al 2004). Yet none of these “breakthroughs” ever translated to human medicine.

What prevents successes in mice from becoming human cures and treatments? The reason is largely a simple one, as we showed when we recently analyzed the reputed contributions of mouse experiments to human type 2 diabetes research (Chandrasekera and Pippin 2013). … Continue Reading

What Will the World Inherit From GE Salmon?

Salmon Farming

By Dr. Gerry Goeden

It’s true; about 50 percent of the fish we eat are farmed. There is good reason for this as, one by one, the world’s commercial fisheries collapse through overfishing. According to FAO (2010), 70% of the world’s large commercial fisheries have either failed or are not far from it.

When things started to go wrong with world fisheries, fish farming was hailed as the ultimate solution. Fish could be produced cheaply and pressure removed from wild stocks. It seemed like the perfect solution to a very big problem. … Continue Reading

Edward Snowden’s Testimony to the European Parliament on NSA Spying and its Consequences

Edward Snowden Barton Gellman/Getty Images

Independent Science News has decided to reprint (1) in full the March 7th testimony of Edward Snowden to the European Parliament. Snowden’s testimony is vitally important for every citizen in every country to understand, yet it has barely been covered by the commercial or (non-commercial) global media. At stake is the possibility of individuals and organizations (not just the media) to function as checks on executive power. It also demonstrates the ability of a secret agency to become an executive power, able even to control the spy services of foreign countries. Publication here will enable ISN readers to hear from Snowden himself about what he considers the scope and significance of ‘suspicionless surveillance’ … Continue Reading

The Health Care Doctors Forgot: Why Ordinary Food Will Be the Future of Medicine

February 3, 2014 Commentaries, Health 16 Comments
Apple and a Pear

by T Colin Campbell, Jacob Gould Schurman Professor Emeritus, Cornell University

Few issues have become so intensely debated and politically charged as the need to reform the health care system. This debate has resulted in the ObamaCare program (The Affordable Care Act), which aims to expand and improve health care, thereby reducing health care costs.

Presently, US health care costs constitute 18% of GDP, up from about 5% around 1970 (1). These costs are burdensome and many sectors of our society are paying the price. School programs are being scaled back because of the escalating costs of retiree health care benefit programs, as illustrated in Michigan where they are “laying off teachers, scrapping programs and mothballing extracurricular activities…[because of]…health care bills of retirees.“(2). … Continue Reading

Fakethrough! GMOs and the Capitulation of Science Journalism

by Jonathan Latham, PhD

Good journalism examines its sources critically, it takes nothing at face value, places its topics in a historical context, and it values above all the public interest. Such journalism is, most people agree, essential to any equitable and open system of government. These statements are, if anything, especially applicable to the science media. But while the media in general has recently taken much criticism, for trivialising news and other flaws, the science media has somehow escaped serious attention. This is unfortunate because no country in the world has a healthy science media. … Continue Reading

The Founding Fables of Industrialised Agriculture

Farming in Italy

by Colin Tudge

Governments these days are not content with agriculture that merely provides good food. In line with the dogma of neoliberalism they want it to contribute as much wealth as any other industry towards the grand goal of “economic growth”. High tech offers to reconcile the two ambitions – producing allegedly fabulous yields, which seems to be what’s needed, and becoming highly profitable. The high-tech flavour of the decade is genetic engineering, supplying custom-built crops and livestock as GMOs (Genetically Modified Organisms). … Continue Reading

Poor Numbers: How We Are Misled by African Development Statistics

by Morten Jerven Associate Professor, Simon Fraser University, Canada

On 5 November 2010, Ghana Statistical Services announced that it was revising national GDP estimates upwards by over 60 percent. After the revision a range of new activities, worth about US$13 billion, were accounted for, and Ghana was thus upgraded from a low-income country to a lower-middle-income country. In the fall of 2011 its near-neighbor Nigeria also announced a forthcoming revision of its GDP. This revision is not yet complete, but it has been suggested that the GDP revision in Nigeria will cause a similarly large jump in GDP. If GDP doubles in Nigeria following the revision it will mean that the GDP for the whole region increases by more than 15 percent. The value of the increase amounts to as much as 40 economies roughly the size of Malawi’s.
… Continue Reading

Still Chasing Ghosts: A New Genetic Methodology Will Not Find the “Missing Heritability”

September 19, 2013 Commentaries, Health 26 Comments
Search for the missing heritability

By Evan Charney, Duke Institute for Brain Science, Duke University

One of the hopes and promises of the Human Genome Sequencing Project was that it would revolutionize the understanding, diagnosis, and treatment of most human disorders. It would do this by uncovering the supposed “genetic bases” of human behavior. With a few exceptions, however, the search for common gene variants -“polymorphisms” – associated with common diseases has borne little fruit. And when such associations have been found the polymorphisms seem to have little predictive value and do little to advance our understanding of the causes of disease. In a 2012 study, for example, researchers found that incorporating genetic information did not improve doctors’ ability to predict disease risk for breast cancer, Type 2 diabetes, and rheumatoid arthritis [1]. … Continue Reading

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Commentaries

The UK’s Royal Society: a Case Study in How the Health Risks of GMOs Have Been Systematically Misrepresented

by Steven Druker For more than twenty years, many eminent scientists and scientific institutions have routinely claimed that genetically modified foods are safe. And because of the perceived authority of their pronouncements, most government officials and members of the media have believed them. But when the arguments these scientists employ …

“Poison Papers” Snapshot: HOJO Transcript Illustrates EPA Collusion With Chemical Industry

The Poison Papers

by Rebekah Wilce The world of independent chemical testing has a shiny veneer. The public is reassured that chemicals they’re exposed to on a daily basis are certified by technicians in spotless white lab coats who carefully conduct scientific studies, including on animals in neat rows of cages. But a …

The Biotech Industry Is Taking Over the Regulation of GMOs from the Inside

by Jonathan Latham, PhD The British non-profit GMWatch recently revealed the agribusiness takeover of Conabia, the National Advisory Committee on Agricultural Biotechnology of Argentina. Conabia is the GMO assessment body of Argentina. According to GMWatch, 26 of 34 its members were either agribusiness company employees or had major conflicts of …

The Meaning of Life (Part I)

DNA double helix

by Jonathan Latham, PhD Many people date the DNA revolution to the discovery of its structure by James Watson and Francis Crick in 1953. But really it began thirty years before, conceived by the mind of John D Rockefeller, Sr. Thus it is fitting that DNA is named after him. …

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Reviews

Poison Spring: The Secret History of Pollution and the EPA

Poison Spring Evaggelos Valllianatos

Book Author: Evaggelos Vallianatos with McKay Jenkins Reviewed by: Carol Van Strum “Science is the belief in the ignorance of experts,” Richard Feynman famously declared in 1966. Ever quick to challenge accepted wisdom, he distinguished the laudable ignorance of science, forever seeking unattainable certainties, from the dangerous ignorance of experts …

The Real Cost of Fracking: How America’s Shale Gas Boom Is Threatening Our Families, Pets, and Food

The Real Cost of Fracking book cover

Book Authors: Michelle Bamberger and Robert Oswald Reviewed by Allison Wilson (The Bioscience Resource Project) The first researchers to systematically document ill health in livestock, pets, and people living near fracking drill sites were Michelle Bamberger and Robert Oswald. Bamberger, a veterinarian, and Oswald, a professor of molecular medicine at …

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