The Meaning of Life (Part I)

by Jonathan Latham, PhD

Many people date the DNA revolution to the discovery of its structure by James Watson and Francis Crick in 1953. But really it began thirty years before, conceived by the mind of John D Rockefeller, Sr. Thus it is fitting that DNA is named after him. DNA stands for DeoxyriboNucleic Acid and ribo stands for Rockefeller Institute of Biochemistry (now Rockefeller University) where the chemical composition of DNA was first discovered in the 1920s. The Rockefeller Foundation had become interested in DNA because its trustees feared a Bolshevik-style revolution. Intense public resentment had already compelled the break-up of their Standard oil Company in 1911; so the Foundation sought ways, said trustee Harry Pratt Judson in 1913, to “reinforce the police power of the state”. They intended to find the ultimate key to human behaviour which would allow the resentful and envious mobs to be effectively managed.
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Gene Drives: A Scientific Case for a Complete and Perpetual Ban

by Jonathan Latham, PhD

One of the central issues of our day is how to safely manage the outputs of industrial innovation. Novel products incorporating nanotechnology, biotechnology, rare metals, microwaves, novel chemicals, and more, enter the market on a daily basis. Yet none of these products come with an adequate data set of scientific information. Nor do they come with a clear intellectual framework within which their risks can be placed, as disputes over the precautionary principle show. The majority of products receive no regulatory supervision at all. How will the product be disposed of? What populations and which ecosystems will be exposed in the course of its advertised uses? What will be the consequences of accidental, off-label or illegal uses? Typically, none of these kinds of questions are adequately asked by government regulatory agencies unless citizens actively prod them to do so. … Continue Reading

Genetics Is Giving Way to a New Science of Life

by Jonathan Latham, PhD

Test your understanding of the living world with this simple question. What kind of large biomolecule is found in all living organisms? If your answer is “DNA”, you are incorrect. Many organisms contain no DNA at all.

The mistake is very forgivable though. A standard biology education casts DNA (DeoxyriboNucleic Acid) as the master molecule of life, coordinating and controlling most, if not all, living functions. This master molecule concept is popular. It is plausible. It is taught in every university and high school. But it is wrong. DNA is no master controller, nor is it even at the centre of biology. Instead, science overwhelmingly shows that life is self-organised. The science of biology is thus awaiting the paradigm shift to end all paradigm shifts. … Continue Reading

God’s Red Pencil? CRISPR and The Three Myths of Precise Genome Editing

by Jonathan Latham, PhD

For the benefit of those parts of the world where public acceptance of biotechnology is incomplete, a public relations blitz is at full tilt. It concerns an emerging set of methods for altering the DNA of living organisms. “Easy DNA Editing Will Remake the World. Buckle Up“; “We Have the Technology to Destroy All Zika Mosquitoes“; and “CRISPR: gene editing is just the beginning”. (CRISPR is short for CRISPR/cas9, which is short for Clustered Regularly-Interspaced Short Palindromic Repeats/CRISPR associated protein 9; Jinek et al., 2012. It is a combination of a guide RNA and a protein that can cut DNA.) … Continue Reading

Genetic Testing of Citizens Is a Backdoor into Total Population Surveillance by Governments and Companies

by Helen Wallace, GeneWatch UK

The new Chief Executive of the National Health Service (NHS) in England, Simon Stevens, was recently reported arguing that the NHS must be transformed to make people’s personal genetic information the basis of their treatments (1).

His proposition is unsurprising since it is in line with the efforts of successive UK governments to build a DNA database in the NHS in England by stealth. In particular, sequencing every baby at birth and storing whole genomes in electronic medical records is a plan backed by Health Secretary Jeremy Hunt (2). The current version of this plan would involve sharing whole or partial DNA sequences (genomes or genotypes) with companies like Google … Continue Reading

Still Chasing Ghosts: A New Genetic Methodology Will Not Find the “Missing Heritability”

By Evan Charney, Duke Institute for Brain Science, Duke University

One of the hopes and promises of the Human Genome Sequencing Project was that it would revolutionize the understanding, diagnosis, and treatment of most human disorders. It would do this by uncovering the supposed “genetic bases” of human behavior. With a few exceptions, however, the search for common gene variants -“polymorphisms” – associated with common diseases has borne little fruit. And when such associations have been found the polymorphisms seem to have little predictive value and do little to advance our understanding of the causes of disease. In a 2012 study, for example, researchers found that incorporating genetic information did not improve doctors’ ability to predict disease risk for breast cancer, Type 2 diabetes, and rheumatoid arthritis [1]. … Continue Reading

Science and Social Control: Political Paralysis and the Genetics Agenda

By Jonathan Latham, PhD (Originally posted July 31st and lost after a DDOS (electronic) attack).

Variations in individual “educational attainment” (essentially, whether students complete high school or college) cannot be attributed to inherited genetic differences. That is the finding of a new study reported in Science magazine (Rietveld et al. 2013). According to this research, fully 98% of all variation in educational attainment is accounted for by factors other than a person’s simple genetic makeup.

This implies that essentially all of student success is a consequence of potentially alterable social or environmental factors. This is an important and perhaps surprising observation, of high interest to parents, teachers, and policymakers alike; but it did not make the headlines.

The likely reason is that the authors of the study failed to mention the 98% figure in the title or the summary abstract. Nor was it mentioned in the accompanying press release. … Continue Reading

Is the Hidden Viral Gene Safe? GMO Regulators Fail to Convince

by Jonathan Latham, PhD and Allison Wilson, PhD

Having unwittingly allowed a viral gene into the food chain, the response of regulators so far has been to release statements intended to allay public concerns. These statements, however, are inadequate to meet a potentially major food crisis. Not only do they fail to address important issues but they are also scientifically questionable even within their chosen frame of reference.

The GMO regulators involved are the European Food Safety Authority (EFSA) and Food Standards Australia New Zealand (FSANZ). These two agencies have separately released statements (see complete texts EFSA and FSANZ) defending their risk assessments and conclusions in response to our recent article “Regulators Discover a Hidden Viral Gene in GMO crops“. … Continue Reading